Epigenetic treatment of neurodegenerative ophthalmic disorders: an eye toward the future.
Date
2017
Authors
Moos, Walter H.
Faller, Douglas V.
Glavas, Ioannis P.
Harpp, David N.
Irwin, Michael H.
Kanara, Iphigenia
Pinkert, Carl A.
Powers, Whitney R.
Steliou, Kosta
Vavvas, Demetrios G.
Version
Published version
OA Version
Citation
Walter H. Moos, Douglas V. Faller, Ioannis P. Glavas, David N. Harpp, Michael H. Irwin, Iphigenia Kanara, Carl A. Pinkert, Whitney R. Powers, Kosta Steliou, Demetrios G. Vavvas, Krishna Kodukula. 2017. "Epigenetic Treatment of Neurodegenerative Ophthalmic Disorders: An Eye Toward the Future.." Biores Open Access, Volume 6, Issue 1, pp. 169 - 181. https://doi.org/10.1089/biores.2017.0036
Abstract
Eye disease is one of the primary medical conditions that requires attention and therapeutic intervention in ageing populations worldwide. Further, the global burden of diabetes and obesity, along with heart disease, all lead to secondary manifestations of ophthalmic distress. Therefore, there is increased interest in developing innovative new approaches that target various mechanisms and sequelae driving conditions that result in adverse vision. The research challenge is even greater given that the terrain of eye diseases is difficult to landscape into a single therapeutic theme. This report addresses the burden of eye disease due to mitochondrial dysfunction, including antioxidant, autophagic, epigenetic, mitophagic, and other cellular processes that modulate the biomedical end result. In this light, we single out lipoic acid as a potent known natural activator of these pathways, along with alternative and potentially more effective conjugates, which together harness the necessary potency, specificity, and biodistribution parameters required for improved therapeutic outcomes.
Description
License
Copyright Walter H. Moos et al. 2017; Published by Mary Ann Liebert, Inc. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.