Rapid changes in synaptic strength after mild traumatic brain injury
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Date
2019
Authors
Witkowski, Ellen D.
Gao, Yuan
Gavsyuk, Alexander F.
Maor, Ido
DeWalt, Gloria J.
Eldred, William D.
Mizrahi, Adi
Davison, Ian G.
Version
Published version
OA Version
Citation
E.D. Witkowski, Y. Gao, A.F. Gavsyuk, I. Maor, G.J. DeWalt, W.D. Eldred, A. Mizrahi, I.G. Davison. 2019. "Rapid Changes in Synaptic Strength After Mild Traumatic Brain Injury." Frontiers in Cellular Neuroscience, Volume 13, pp.166-. https://doi.org/10.3389/fncel.2019.00166
Abstract
Traumatic brain injury (TBI) affects millions of Americans annually, but effective treatments remain inadequate due to our poor understanding of how injury impacts neural function. Data are particularly limited for mild, closed-skull TBI, which forms the majority of human cases, and for acute injury phases, when trauma effects and compensatory responses appear highly dynamic. Here we use a mouse model of mild TBI to characterize injury-induced synaptic dysfunction, and examine its progression over the hours to days after trauma. Mild injury consistently caused both locomotor deficits and localized neuroinflammation in piriform and entorhinal cortices, along with reduced olfactory discrimination ability. Using whole-cell recordings to characterize synaptic input onto piriform pyramidal neurons, we found moderate effects on excitatory or inhibitory synaptic function at 48 h after TBI and robust increase in excitatory inputs in slices prepared 1 h after injury. Excitatory increases predominated over inhibitory effects, suggesting that loss of excitatory-inhibitory balance is a common feature of both mild and severe TBI. Our data indicate that mild injury drives rapidly evolving alterations in neural function in the hours following injury, highlighting the need to better characterize the interplay between the primary trauma responses and compensatory effects during this early time period.
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Copyright © 2019 Witkowski, Gao, Gavsyuk, Maor, DeWalt, Eldred, Mizrahi and Davison. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.